Inverse Relationship Between Serum Alkaline Phosphatase and Calcium in Osteoarthritis Patients

Abstract

Osteoarthritis (OA) is a progressive degenerative joint disorder characterized by biochemical and structural alterations in cartilage and surrounding tissues. This study aimed to evaluate the correlation between serum alkaline phosphatase (ALP) activity and serum calcium levels in osteoarthritis patients compared with healthy controls to identify deviations from normal physiological ranges. A total of 100 clinically diagnosed OA patients (61% male, 39% female), aged 45 years and above, were recruited from the outpatient department of Teaching Hospital Shahdara, and their serum samples were analyzed for ALP and calcium concentrations. Findings revealed elevated serum ALP levels and comparatively lower serum calcium levels in OA patients. An inverse relationship was observed between these two biochemical parameters, suggesting their potential utility as inexpensive and accessible biomarkers for assessing osteoarthritis severity.